Dihalogenated ferrocenes and processes for the preparation thereof

US5925778A · kind A · utility

Assignee

• Novartis AG · CH

Inventor

• Benoit Pugin · Münchenstein, CH

Key dates

• Filing date: Oct 9, 1997
• Grant date: Jul 20, 1999
• Expiry date: Oct 9, 2017

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/50
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

The invention relates to a compound of formula (I), wherein R.sub.1 is C.sub.1 -C.sub.8 alkyl, phenyl or phenyl substituted by from 1 to 3 C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy substituents; R.sub.2 and R.sub.3 are each independently of the other hydrogen or C.sub.1 -C.sub.12 alkyl; and Hal is F, Cl, Br or I. Compounds of formula (I) are valuable intermediates for compounds of formula (III) which are also a subject of this invention, wherein R.sub.1, R.sub.2, R.sub.3 and Hal are as defined above; R.sub.10 and R.sub.11 are identical or different and are C.sub.1 -C.sub.12 alkyl, C.sub.5 -C.sub.12 cycloalkyl, phenyl, C.sub.5 -C.sub.12 cycloalkyl substituted by C.sub.1 -C.sub.4 alkyl or by C.sub.1 -C.sub.4 alkoxy, or phenyl substituted by from one to three C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, --SiR.sub.4 R.sub.5 R.sub.6, halogen, --SO.sub.3 M, --CO.sub.2 M, --PO.sub.3 M, --NR.sub.7 R.sub.8, --.sup.+ NR.sub.7 R.sub.8 R.sub.9 !X.sup.- or C.sub.1 -C.sub.5 fluoroalkyl substituents; or the group --PR.sub.10 R.sub.11 is a radical of formula (IV, IVa, IVb or IVc); R.sub.4, R.sub.5 and R.sub.6 are each independently of the others C.sub.1 -C.sub.12 alkyl or phenyl; R.sub…