Methods for gene transfer
US5928638A · kind A · utility
41Cited by
7References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 17, 1996 |
| Grant date | Jul 27, 1999 |
| Priority date | — |
| Expiry date | Jun 17, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a method for optimizing gene transfer into hematopoietic stem cells (HSCs) by contacting the cells with hydroxyurea prior to gene transfer to induce HSCs in G0 into active cell cycle. This method is useful for treating patients suffering from a disease that is suitably treated by gene therapy or involves hematopoietic cells. A method is also provided for enhancing the efficacy of bone marrow transplantation by administering hydroxyurea to increase HSC yields.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.