Lymphatic delivery methods
US5928669A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 15, 1998 |
| Grant date | Jul 27, 1999 |
| Priority date | — |
| Expiry date | Jun 15, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/6933
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A composition for delivering an active agent to the lymphatic system comprises a plurality of colloidal particles and an active agent associated with each particle, wherein the surface of each particle has a hudrophobicity ratio as defined of less than 10, or wherein a modifying agent is adsorbed onto the surface of each particle such that the modifying agent gives an advancing contact angle as defined of less than 60.degree. or wherein the adsorbed layer thickness as defined is less than 10 nm or the albumin uptake ratio is between 0.2 and 0.5. The composition may satisfy one or more of these requirements. Preferred modifying agents are non-ionic surfactants, in particular block copolymers containing polyethyleneglycol.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.