Therapeutic method for management of diabetes mellitus

US5929055A · kind A · utility

Assignee

• The Research Foundation of the State University of New York · US

Inventors

• Maria Ryan · Port Jefferson Station, US
• Lorne M. Golub · Smithtown, US
• Nungavaram S. Ramamurthy · Smithtown, US
• Thomas F. McNamara · Port Jefferson, US

Key dates

• Filing date: Jun 23, 1997
• Grant date: Jul 27, 1999
• Expiry date: Jun 23, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P3/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method for treating diabetes in a mammal by moderately controlling blood glucose concentration in the mammal together with administering to the mammal an amount of a tetracycline compound effective to reduce complications associated with diabetic hyperglycemia. The method enables long term management of diabetes by avoiding the problems associated with tight control of blood glucose concentrations, i.e., hypoglycemia tolerance and seizures, while simultaneously avoiding the problems associated with conventional moderate control of blood glucose concentrations, i.e., pathological complications associated with hyperglycemia, such as nephropathy, retinopathy, etc. Blood glucose concentration can be controlled by moderate administration (e.g., fewer injections per day) of insulin or another glucose-modulating agent, while pathological complications characteristic of diabetic hyperglycemia are ameliorated through the activity of tetracycline compound, the latter preferably administered in an amount that is substantially non-antimicrobial.