Method for treating diseases mediated by cellular proliferation in response to PDGF, EGF, FGF and VEGF
US5929081A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 7, 1995 |
| Grant date | Jul 27, 1999 |
| Priority date | — |
| Expiry date | Jun 7, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/522
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There is disclosed a method for: PA1 (1) inhibiting new blood vessel formation that is useful for treating or preventing progression of diabetic retinopathy, cavernous haemangiomas, Kaposi's sarcoma, tumors composed of endothelial-like cells, and growth of cancer cells by preventing their development of a new blood supply: PA1 (2) suppressing development of kidney diseases due to cytokine induced proliferation of mesangial cells and/or glomerular epithelial cells that is useful for treating or preventing progression of diabetic glomerulosclerosis and other glomerulonephritides of various types and etiologies; PA1 (3) preventing joint destruction accompanying rheumatoid arthritis due to proliferation of synovial cells; PA1 (4) suppressing manifestations of psoriasis due to proliferation of keratinocytes and accumulation of inflammatory cells; PA1 (5) suppressing accelerated atherogenesis involved in restenosis of coronary vessels or other arterial vessels following angioplasty; PA1 (6) suppressing atherogenesis, coronary artery disease and other vasculopathies due to atherogenesis; and PA1 (7) suppressing tumor growth via paracrine or autocrine mediated responses to PDGF, FGF EGF or…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.