Process for the preparation of carboxylic acid succinimidyl esters

US5929251A · kind A · utility

Assignee

• DSM Fine Chemicals Austria GmbH · AU

Inventors

• Peter Pochlauer · Dordrecht, NL
• Wolfram Hendel · Leonding, AT
• Christian Burger · Leonding, AT
• Anita Lamplmayr · Linz, AT
• Harald Poschko · Ansfelden, AT
• Antonia Praus · Linz, AT
• Gerald Summer · Linz, AT

Key dates

• Filing date: Dec 30, 1997
• Grant date: Jul 27, 1999
• Expiry date: Dec 30, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D207/46
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Process for the preparation of carboxylic acid succinimidyl esters by reaction of N-hydroxysuccinimide with a carboxylic acid and a halophosphoric acid ester of the formula ##STR1## in which R.sub.1 and R.sub.2 are identical or different and are a C.sub.2 - to C.sub.6 -alkyl radical or a phenyl radical, or R.sub.1 and R.sub.2 together form a C.sub.6 -aryl radical, in the presence of a base in a diluent at a temperature of 0.degree. C. up to 100.degree. C. and isolation of the corresponding carboxylic acid succinimidyl ester.