Gelatin or collagen hydrolysate containing drug formulation that provides for immediate release of nanoparticle drug compounds

US5932245A · kind A · utility

Assignee

• ALFATEC-Pharm GmbH · DE

Inventors

• Jens-Christian Wunderlich · Heidelberg, DE
• Ursula Schick · Schriesheim, DE
• Jurgen Werry · Ludwigshafen, DE
• Jurgen Freidenreich · Schriesheim, DE

Key dates

• Filing date: Oct 25, 1994
• Grant date: Aug 3, 1999
• Expiry date: Oct 25, 2014

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/915
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Nanosols and process for preparing the same allow colloidally dispersed solutions of scarcely water-soluble active substances to be stabilized with gelatin or its derivatives, by partly or fully setting the iso-ionic point (IIP, equivalent to a neutral charge) between the gelatin and the surface charged active substance particles. In order to neutralize the charge of the system composed of active substance particles and gelatin, the surface charge of the particles is compensated by a corresponding opposite charge of the gelatin molecules. For that purpose, a determined charge in relation to the isoelectric point (IEP) and the pH value of the solution is set on the gelatin molecules. By stabilizing in this way the practically monodispersed state thus generated, the Ostwald maturation of the colloidal particles of scarcely soluble active substance is strongly reduced. A new form of pharmaceutical administration having new properties can thus be obtained with generally scarcely water-soluble inorganic and organic compounds, in particular medicaments with a problematic bioavailablity. Preferred medicaments are glibenclamide and 3-indolylacetic acid derivatives, such as indomethacin or …