PDGF receptor kinase inhibitory compounds their preparation and compositions

US5932580A · kind A · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Alexander Levitzki · Melrose, US
• Aviv Gazit · Jerusalem, IL
• Shmuel Banai · Jerusalem, IL
• S. David Gertz · Jerusalem, IL
• Gershon Golomb · Beer Sheva, IL

Key dates

• Filing date: Dec 1, 1997
• Grant date: Aug 3, 1999
• Expiry date: Dec 1, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

PDGF receptor kinase inhibitory compounds of the quinoxaline family, methods for their synthesis and containment is slow release pharmaceutical preparations, and their use for treatment of proliferative malignant and non-malignant diseases or disorders by local or systemic application. A compound according to the invention includes a tyrphostin of the general formula: ##STR1## wherein R1 and R2 are each independently selected from the group consisting of alkyl, alkoxy, halogen, nitro and amine and Ar is selected from the group consisting of phenyl, ferrocene, thiophene, furane, pyrrole, indole, thiazole, imidazole and pyridine.