3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors
US5932733A · kind A · utility
9Cited by
5References
56Claims
0Family size
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Key dates
| Filing date | Jun 7, 1995 |
| Grant date | Aug 3, 1999 |
| Priority date | — |
| Expiry date | Jun 7, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/06191
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses peptide aldehydes having a lactam group as part of the peptide backbone and having an original mimic group such as an amidinopiperidine or amidinophengyl tail. These compounds are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.