Process for the preparation of cis-hexahydroisoindoline derivatives
US5932744A · kind A · utility
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2References
5Claims
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Assignee
Inventors
Key dates
| Filing date | Aug 4, 1998 |
| Grant date | Aug 3, 1999 |
| Priority date | — |
| Expiry date | Aug 4, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/44
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The instant invention provides a process for the industrial preparation of cis-hexahydroisoindoline derivatives in high yields and stereoselective manner. The instant invention relates to a process for the preparation of cis-hexahydroisoindoline derivative of formula II ##STR1## wherein R.sup.2 is hydrogen, alkyl, benzyl, acyl or alkoxycarbonyl, by catalytic reduction of isoindoline derivative of formula I ##STR2## wherein R.sup.1 is hydrogen, alkyl, benzyl, acyl or alkoxycarbonyl, wherein the catalytic reduction is carried out in the presence of a ruthenium, a rhodium or a palladium catalyst.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.