Process for the production .beta.-amino-.alpha.-hydroxycarboxylic acids and derivatives thereof

US5932758A · kind A · utility

Assignee

• Degussa AG · DE

Inventors

• Klaus Stingl · Alzenau, DE
• Matthias Kottenhahn · Alzenau, DE
• Karlheinz Drauz · Alzenau, DE

Key dates

• Filing date: Jun 1, 1998
• Grant date: Aug 3, 1999
• Expiry date: Jun 1, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C269/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed is a process for producing .beta.-amino-.alpha.-hydroxycarboxylic acid derivatives of general formula (2R,3S)- or (2S,3E)-N-(X,Y)-3-amino-2-hydroxy-3-phenyl propionic acid-Z of Formula I, ##STR1## e.g. of (2E,3S)-3-amino-2-hydroxy-3-phenyl propionic acid or (2R,3S)-N-benzoyl-3-amino-2-hydroxy-3-phenyl propionic acid methylester. Compounds of type I are valuable intermediates in the total synthesis of Taxols which can be used in the treatment of various forms of cancer.