Nasal drug delivery composition containing nicotine
US5935604A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jul 1, 1996 |
| Grant date | Aug 10, 1999 |
| Priority date | — |
| Expiry date | Jul 1, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P27/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a nasal drug delivery composition comprising nicotine or a pharmacologically-acceptable salt or derivative thereof wherein the composition is adapted to delivery a pulse of nicotine for rapid absorption and a controlled release of nicotine for subsequent sustained absorption. The controlled release phase can be achieved by providing an ion-exchange material which will form a complex with the nicotine. The ion-exchange material may be a polymeric material such as a polysaccharide, or may be in the form of bioadhesive ion-exchange microspheres. The pulse release can be achieved by overloading the ion-exchange material with nicotine so that the composition contains some excess nicotine for immediate release and absorption. Alternatively, some nicotine may be associated with a non ion-exchange material which will release the nicotine immediately on contact with the nasal mucosa, for example non-ion-exchange bioadhesive microspheres.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.