Muscarinic antagonists
US5935958A · kind A · utility
38Cited by
3References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 26, 1997 |
| Grant date | Aug 10, 1999 |
| Priority date | — |
| Expiry date | Jun 26, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D311/74
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Di-N-substituted piperazine or 1,4-di-substituted piperidine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) ##STR1## wherein Q, n, R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.21, R.sup.27, R.sup.28, X, and Z are as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations with acetyl-cholinesterase inhibitors of compounds capable of enhancing acetylcholine release and having the above formula.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.