Tolerability of pharmaceutically active .beta.-amino acids

US5935988A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Michael Matzke · Wuppertal, DE
• Hans-Christian Militzer · Odenthal, DE
• Joachim Mittendorf · Wuppertal, DE
• Franz Kunisch · Odenthal, DE
• Axel Schmidt · Munich, DE
• Wolfgang Schonfeld · Wuppertal, DE
• Karl Ziegelbauer · Wuppertal, DE

Key dates

• Filing date: Jul 12, 1996
• Grant date: Aug 10, 1999
• Expiry date: Jul 12, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to mixtures of .alpha.-amino acids and/or derivatives thereof and cyclopentane-.beta.-amino acids and/or derivatives thereof, dipeptides of the abovementioned .alpha.-amino acids and cyclopentane-.beta.-amino acids and mixtures of the abovementioned mixtures and dipeptides which have an improved tolerability in warm-blooded animals compared with the pure cyclopentane-.beta.-amino acids.