Solid phase synthesis of oligonucleotides

US5936077A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Wolfgang Pfleiderer · Konstanz, DE
• Markus Beier · Heidelberg, DE

Key dates

• Filing date: Jul 11, 1997
• Grant date: Aug 10, 1999
• Expiry date: Jul 11, 2017

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process is described for preparing oligonucleotides by solid phase synthesis in which exocyclic amino groups present on nucleobases are protected with cyclic diacyl groups, which can be deprotected in the presence of a strong, nonnucleophilic base. Novel intermediates employing the cyclic diacyl protecting groups are also described.