Process for chiral enrichment of optically active carboxylic acids or salts or esters thereof
US5936118A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Apr 4, 1997 |
| Grant date | Aug 10, 1999 |
| Priority date | — |
| Expiry date | Apr 4, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C51/487
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A highly efficient method for enriching the chiral purity of a partially enriched mixture of enantiomers of an optically active compound, a major portion of the partially enriched mixture of enantiomers comprising a first enantiomer of the optically active compound, a minor portion of the partially enriched mixture of enantiomers comprising a second enantiomer of the optically active compound. The method comprises mixing an acid in whatever form it may exist in solution with an aqueous solution of the partially enriched mixture of enantiomers, in whatever form the partially enriched mixture of enantiomers may exist in solution, to form a reaction mass comprising a further enriched mixture of enantiomers of the optically active compound, the further enriched mixture of enantiomers having a higher percentage of the first enantiomer than the partially enriched mixture. The optically active compound has the formula: EQU R.sup.1 R.sup.2 R.sup.3 CCOOZ where R.sup.1, R.sup.2, and R.sup.3 are different from each other and are selected from the group consisting of a hydrogen atom, hydrocarbyl groups, hydrocarbyloxy groups, hydrocarbylthio groups, hydrocarbylcarbonyl groups, halohydrocarbyl …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.