Mesangial cell lines as models for the study and treatment of diabetic tissue complications
US5939275A · kind A · utility
1Cited by
0References
9Claims
0Family size
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Key dates
| Filing date | Sep 1, 1995 |
| Grant date | Aug 17, 1999 |
| Priority date | — |
| Expiry date | Sep 1, 2015 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5091
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An isolated and stable clone of mesangial cells which exhibit characteristics of diabetic cells when grown in normal glucose medium. The cells demonstrate an increase in glucose transport over normal mesangial cells and that provides a model for simulating diabetes in mesangial cells. Further, a stable, permanent clone of mesangial cells which underexpress GLUT1 mRNA and protein and which can be used therapeutically has been isolated.
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