Cholesterol disposal fusion enzymes
US5939318A · kind A · utility
4Cited by
7References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 5, 1996 |
| Grant date | Aug 17, 1999 |
| Priority date | — |
| Expiry date | Feb 5, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Fusion enzymes having multiple segments of different biological activity including one segment having P450scc activity and at least one segment having electron-transfer activity for transferring electrons to P450scc are described along with genetic constructs for production of such enzymes and methods for their use. Methods for their use include cholesterol degradation in vitro or in vivo as well as conversion of cholesterol to other useful steroidal products including pregnenolone.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.