Human steroid receptor
US5939322A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 14, 1996 |
| Grant date | Aug 17, 1999 |
| Priority date | — |
| Expiry date | May 14, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Through the use of the novel receptor NER in a screening procedure, TOFA (5-tetradecyloxy)-2-furan-carboxylic acid) has been found to modulate other receptors and to be a potent potentiator of other drugs. TOFA activates the NER receptor. The NER receptor is a novel member of the steroid hormone receptor family and has been prepared by cDNA cloning from a human osteosarcoma SAOS-2/B10 cell library. Also disclosed is the complete sequence of human NER cDNA; a COS stable expression system; the expressed NER protein; and an assay using the COS expression system. In addition, the invention relates to a method for identifying functional ligands of the NER receptor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.