Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors
US5939416A · kind A · utility
8Cited by
6References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 17, 1997 |
| Grant date | Aug 17, 1999 |
| Priority date | — |
| Expiry date | Jun 17, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the following formula useful for inhibiting Ras function and therefore inhibiting or treating the abnormal growth of cells are disclosed: ##STR1## or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof, wherein: PA1 R and R.sup.2 are independently selected from halo; PA1 R.sup.1 and R.sup.3 are independently selected from the group consisting of H and halo, provided that at least one of R.sup.1 and R.sup.3 is H; PA1 R.sup.4 is ##STR2## or R.sup.5 ; R.sup.5 is ##STR3## and the remaining variables are as defined in the specification.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.