2-benzyl-polycyclic guanine derivatives and process for preparing them
US5939419A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 23, 1995 |
| Grant date | Aug 17, 1999 |
| Priority date | — |
| Expiry date | Aug 23, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D473/40
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Antihypertensive and bronchodilating compounds of the formula or a pharmaceutically acceptable salt thereof, and a process for preparing them are disclosed, wherein: PA0 R.sub.1, R.sub.2, R.sub.3, R.sup.a, R.sup.b and R.sup.c as defined in the disclosure; PA1 pharmaceutical compositions containing said compounds; PA1 methods of treatment using said compounds; and PA1 a process for preparing polycyclic guanines comprising PA2 a) reducing a nitrosopyrimidine, and treating the reduced nitrosopyrimidine with an acylating reagent to give the amidopyrimidine; PA2 b) reacting the amidopyrimidine with a halogenating/cyclizing reagent to give a halopurine; PA2 c) reacting, in the presence of a base, the halopurine with an amine to give the substituted aminopurine; and PA2 d) closing the ring of the substituted aminopurine with a suitable dehydrating agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.