Compounds for treating disorders of lipid metabolism and their preparation

US5939424A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Hans Georg Boger · Idstein, DE
• Axel Hoffmann · Berlin, DE
• Gerhard Jahne · Frankfurt, DE
• Norbert Krass · Frankfurt am Main, DE
• Hans-Ludwig Schafer · Hochheim, DE

Key dates

• Filing date: Jun 4, 1997
• Grant date: Aug 17, 1999
• Expiry date: Jun 4, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P3/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to 4-Amino-2-ureidopyrimidine-5-carboxamides of the formula I ##STR1## in which R.sup.1 is H or (C.sub.1 -C.sub.8)-alkyl, where one or more H can be replaced by F; R.sup.2 is selected from the group consisting of F, Cl, Br, H, -O-(C.sub.1 -C.sub.8)-alkyl, and -S-(C.sub.1 -C.sub.8)-alkyl, where the alkyl groups have one or more H replaced by F; R.sup.3 is -O-(C.sub.1 -C.sub.8)-alkyl or -S-(C.sub.1 -C.sub.8)-alkyl, where the alkyl groups have one or more H replaced by F; or R.sup.2 and R.sup.3 together form -O-(C.sub.1 -C.sub.5)-alkylene-O-, where the alkylene portion has one or more H replaced by F; and their physiologically tolerable salts. The invention further provides processes for preparing the compounds of formula I. The compounds are suitable for the treatment of disorders of lipid metabolism.