Crystalline FRAP complex
US5939528A · kind A · utility
21Cited by
0References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 31, 1997 |
| Grant date | Aug 17, 1999 |
| Priority date | — |
| Expiry date | Oct 31, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/1205
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to the human protein FRAP, and in particular to the FKBP12-rapamycin binding domain thereof and to the ternary complex formed by the FRB domain, rapamycin and FKBP12. A new crystalline composition comprising the ternary complex, coordinates defining its three dimensional structure in atomic detail, and uses thereof are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.