Recombinant antibodies specific for a growth factor receptor

US5939531A · kind A · utility

Assignee

• Novartis AG · CH

Inventors

• Winfried Wels · Emmendingen, DE
• Nancy Hynes · Basel, CH
• Ina-Maria Harwerth · Weil am Rhein, DE
• Bernd Groner · Basel, CH
• Norman Hardman · Riehen, CH
• Markus Zwickl · Mittelbiberach, DE

Key dates

• Filing date: Jun 5, 1995
• Grant date: Aug 17, 1999
• Expiry date: Jun 5, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention concerns recombinant antibodies directed to the extracellular domain of the human growth factor receptor c-erbB-2 comprising a light chain variable domain and a heavy chain variable domain of a monoclonal antibody, monoclonal antibodies directed to c-erbB-2 themselves, a method of manufacture of said recombinant antibodies and said monoclonal antibodies, hybridoma cells secreting said monoclonal antibodies, a method of manufacture of said hybridoma cells, DNA coding for the heavy chain variable domain, for the light chain variable domain and for the recombinant antibody, a method of manufacture of said DNA, hybrid vectors suitable for expression of said DNA, host cells transformed with said DNA, and the use of said recombinant antibodies and said monoclonal antibodies in the diagnosis and treatment of tumors.