Assay of free and complexed prostate-specific antigen (PSA)
US5939533A · kind A · utility
Inventors
Key dates
| Filing date | May 19, 1995 |
| Grant date | Aug 17, 1999 |
| Priority date | — |
| Expiry date | May 19, 2015 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/57438
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
According to the method of the invention, immunoassays are applied to measure free PSA as well as a proteinase inhibitor complex. Free PSA and PSA complex are according to the invention measured by a non-competitive immunoassay employing at least two different monoclonal antibodies. The invention is further characterized by that the PSA proteinase inhibitor complex of interest is formed either with .alpha..sub.1 -antichymotrypsin, .alpha..sub.1 -protease inhibitor (API) or .alpha..sub.2 -macroglobulin. Moreover, the invention is characterized by that free PSA, the PSA-proteinase inhibitor complex and their ratio are applied in the diagnosis of patients with prostate cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.