Method of making transgenic mice lacking endogenous heavy chains
US5939598A · kind A · utility
997Cited by
5References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 30, 1992 |
| Grant date | Aug 17, 1999 |
| Priority date | — |
| Expiry date | Jul 30, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/24
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci. The hosts are produced by repetitive transformations of embryonic stem cells by homologous recombination, preferably in conjunction with breeding. Different strategies are employed for recombination of the human loci randomly or at analogous host loci.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.