Electrobiochemical method and system for the determination of an analyte which is a member of a recognition pair in a liquid medium, and electrodes thereof

US5942388A · kind A · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Itamar Willner · Mevaseret Tsiyon, IL
• Arie Dagan · Jerusalem, IL
• Shai Rubin · Binyamina - Givat Ada, IL
• Ron Blonder · Jerusalem, IL
• Azalia Riklin · Jerusalem, IL
• Yael Cohen · Tel Aviv-Yafo, IL

Key dates

• Filing date: Feb 21, 1995
• Grant date: Aug 24, 1999
• Expiry date: Feb 21, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S436/825
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

An elcctrobiochemical system for the determination of the presence and optionally concentration of an analyte in a liquid medium, the system comprising an electrode having immobilized thereon a member of a recognition pair, the other member of said pair being said analyte, the presence of said analyte in the medium resulting in formation of a pair complex, being a complex between said immobilized member and said analyte; the system further comprising redox molecules capable of changing their redox state by accepting electrons from or donating electrons to the electrode; the formation of the pair complex on the electrode bringing a change in the electrical response of the system, whereby the presence and optionally the concentration of said analyte in the medium can be determined.