Crystals of the tyrosine kinase domain of non-insulin receptor tyrosine kinases
US5942428A · kind A · utility
12Cited by
1References
4Claims
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Key dates
| Filing date | Aug 21, 1996 |
| Grant date | Aug 24, 1999 |
| Priority date | — |
| Expiry date | Aug 21, 2016 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/68
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Crystals of the tyrosine kinase domain of cytoplasmic tyrosine kinases and receptor tyrosine kinases that undergo ligand-mediated receptor dimerization are provided. In particular, crystals of a mutant of the tyrosine kinase domain of fibroblast growth factor receptor 1 (FLGK), alone and in complex with a non-hydrolyzable adenosine triphosphate analogue, are provided. Also provided are the high resolution three dimensional structures of crystalline FLGK, both alone and in co-complex with the adenosine triphosphate analogue, as determined by X-ray diffraction.
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