Cyclic peptides that bind to urokinase-type plasminogen activator receptor
US5942492A · kind A · utility
3Cited by
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23Claims
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Key dates
| Filing date | Nov 12, 1996 |
| Grant date | Aug 24, 1999 |
| Priority date | — |
| Expiry date | Nov 12, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Cyclic peptide compounds having 11 amino acids joined by a linking unit L, such that the linear dimension between the C.sup..alpha. carbon of the first amino acid and the C.sup..alpha. carbon of eleventh amino acid is between about 4 and 12 .ANG.ngstrom units; are useful for inhibiting the binding of uPA to the ureceptor. Methods for using the cyclic peptide compounds, and compositions containing them, for inhibiting the growth or metastasis of cancerous tumors are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.