LH-RH antagonists having improved action

US5942493A · kind A · utility

Assignee

• Asta Medica Aktiengesellschaft · DE

Inventors

• Bernhard Kutscher · Maintal, DE
• Michael Bernd · Frankfurt, DE
• Thomas Beckers · Konstanz, DE
• Thomas Klenner · Ingelheim am Rhein, DE
• Peter Emig
• Patricia-Marie Charpentier · Maintal, DE

Key dates

• Filing date: May 28, 1998
• Grant date: Aug 24, 1999
• Expiry date: May 28, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New LH-RH antagonists are disclosed, in particular peptidomimetics and peptides modified in a side chain, their salts with pharmaceutically acceptable acids and a process for preparing these LH-RH antagonists and their salts. The disclosed peptides represent analogues of the luteinising hormone releasing hormone (LH-RH). The disclosed compounds have a high antagonistic power and are free of undesirable side effects, in particular edematogenic effects.