Benzisothiazolyl-substituted aminomethylchromans

US5942529A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Rudolf Schohe-Loop · Wuppertal, DE
• Hans-Georg Heine · Krefeld, DE
• Peter-Rudolf Seidel · Cologne, DE
• Wolfgang Kanhai · Wuppertal, DE
• Joachim Schuhmacher · Wuppertal, DE
• Arno Friedl · Bensberg, DE
• Ervin Horvath · Leverkusen, DE
• Thomas Glaser · Overath, DE
• Reinhard Jork · Haan, DE

Key dates

• Filing date: Jun 13, 1996
• Grant date: Aug 24, 1999
• Expiry date: Jun 13, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D493/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The benzisothiazolyl-substituted aminomethylchromans are prepared either by substituting the corresponding unsubstituted aminomethylchromans on the amine nitrogen or reacting the corresponding benzisothiazolylalkylamines with appropriate activated methylchromans or reacting the amine nitrogen of aminomethylchroman first with an appropriately substituted alkine and then hydrogenating. The benzisothiazolyl-substituted aminomethylchromans can be used as active compounds in medicaments, in particular in medicaments for the treatment of disorders of the central nervous system.