Method of inhibiting the transport of L-glutamate to treat CNS disorders

US5942537A · kind A · utility

Assignee

• The Regents of the University of California · US

Inventors

• A. Richard Chamberlin · Irvine, US
• Richard J. Bridges · Bishop, US
• Carl W. Cotman · Santa Ana, US
• Mark S. Stanley · Pacifica, US

Key dates

• Filing date: Aug 9, 1993
• Grant date: Aug 24, 1999
• Expiry date: Aug 9, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/572
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A method of inhibiting the transport of a neurotransmitter away from the synapse comprising contacting a neurotransmitter transporter with a compound having the structure ##STR1## wherein ##STR2## or CONHR.sup.3 in any combination and and wherein R.sup.2 =OR.sup.3, NR.sup.3.sub.2, alkyl, or substituted alkyl and R.sup.3 =alkyl or substituted alkyl.