2-Deoxystreptamine derivatives, pharmaceutical compositions thereof and therapeutic methods using same

US5942547A · kind A · utility

Assignee

• Scriptgen Pharmaceuticals, Inc. · US

Inventors

• Gary Gustafson · Ridgefield, US
• David G. Powers · Maynard, US
• Mark A. Wuonola · Wilmington, US

Key dates

• Filing date: Sep 6, 1996
• Grant date: Aug 24, 1999
• Expiry date: Sep 6, 2016

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/163
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention provides a compound having the formula: ##STR1## wherein R.sup.1 and R.sup.3 independently are hydrogen, --CHO, --COCH.sub.3, --COR.sup.7, --A--Ar--(Q).sub.z, etc.; wherein D is a C.sub.1-6 linear, C.sub.3-8 branched or cyclic group having from 4 to about 15 atoms, consisting of C, etc.; wherein D is unsubstituted or substituted with one or more groups independently selected from the group consisting of --OH, NH.sub.2, --NHR.sub.7, etc.; wherein each Q is independently --CNH(NHY), --NHCNH(NHY), --SO.sub.2 W, --SOW, etc.; wherein Y is hydrogen, alkyl, alkenyl, --B--NH.sub.2, --B--NHR.sup.8, etc.; wherein W is alkyl, alkenyl, --B--NH.sub.2, etc.; wherein A nd B independently are a bond, or a C.sub.1-6 linear, C.sub.3-8 branched or cyclic linking group having from 1 to about 15 atoms, consisting of C, optionally interrupted by N, S, P and O; wherein A and B independently are unsubstituted or substituted with --OH, NH.sub.2, etc.; wherein R.sup.7 is an alkyl, a branched alkyl, etc.; wherein R.sup.8, R.sup.9, and R.sup.10 are independently represented by hydrogen, alkyl, branched alkyl, etc.; wherein x is 0, 1 or 2; and z is 0, 1, 2, or 4; wherein R.sup.1 ' and R.sup.3 ' …