N-oxides of amino containing pyrido 2,3-D! pyrimidines
US5945422A · kind A · utility
45Cited by
5References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 29, 1998 |
| Grant date | Aug 31, 1999 |
| Priority date | — |
| Expiry date | Jan 29, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
N-oxides of amino containing 6-aryl pyrido2,3-d!-pyrimidine 7-imines, 7-ones, and 7-thiones have the formula ##STR1## where A and B are linkers, Ar is aryl, R.sub.2 is aklyl, X is O, S, or NH, or NAcyl, and R.sub.5 and R.sub.6 are alkyl. The compounds are inhibitors of protein tyrosine kinases and cyclin-dependent kinases, and are thus useful in treating cellular proliferation mediated thereby. The compounds are especially useful in treating cancer, atherosclerosis, restenosis, and psoriasis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.