Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
US5945427A · kind A · utility
2Cited by
10References
33Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 6, 1998 |
| Grant date | Aug 31, 1999 |
| Priority date | — |
| Expiry date | Jan 6, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D409/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is directed to derivatives of 5-thia- and 5-selenopyrimidinone are useful as inhibitors of the enzyme glycimide ribonucleotide formyl transferase (GARFT) and amino imidozole carboxamide ribonucleotide formyl transferase (AICARFT), pharmaceutical compositions containing these derivatives, and methods of using these derivatives. The present invention is also directed to intermediates useful for preparing these derivatives and methods of preparing these intermediates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.