2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives

US5945454A · kind A · utility

Assignee

• Pharmacia & Upjohn S.p.A. · IT

Inventors

• Paolo Pevarello · Pavia, IT
• Raffaella Amici · Piacenza, IT
• Mario Varasi · Milano, IT
• Alberto Bonsignori · Milano, IT
• Patricia Salvati · Arese, IT

Key dates

• Filing date: Jan 8, 1998
• Grant date: Aug 31, 1999
• Expiry date: Jan 8, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C323/36
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel 2(4-substituted)-benzylamino-2-methyl-propanamides compounds, having CNS activity, of general formula (I) wherein: n is zero, 1, 2 or 3; X is --O--, --S--, --CH.sub.2 -- or --NH--; each of R and R.sub.1 independently is hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, hydroxy, C.sub.1 -C.sub.4 alkoxy or trifluoromethyl; each of R.sub.2, R.sub.3 and R.sub.4 independently is hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.3 -C.sub.7 cycloalkyl; and the pharmacetically acceptable salts thereof, are disclosed. ##STR1##