Process for preparing biologically compatible polymers and their use in medical devices
US5945457A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 1, 1997 |
| Grant date | Aug 31, 1999 |
| Priority date | — |
| Expiry date | Oct 1, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S524/916
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A hemocompatible composition comprising a polymer containing at least one pharmacologic material chemically bonded to a polymer backbone. Such compositions may be obtained by reacting a pharmacologic material with a compound containing a polymerizable group (e.g., an acyl halide) and thereafter either copolymerizing the acylated material with one or more copolymerizable monomers or first irradiating a backbone polymer and thereafter grafting the acylated pharmacologic material onto the irradiated polymer. The resulting products are hemocompatible and may be used in the manufacture of medical devices which come in contact with blood or other bodily fluids. The advantage of chemically bonded pharmacologic materials is that they are not leached out and retain their pharmaceutical effectiveness for a long period of time. The compositions may contain one or more additional pharmacologic materials which are physically admixed with polymers containing bonded pharmacologic materials.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.