Method of enhancing the analgesic efficacy of locally and topically administered opioids and other local anesthetics
US5948389A · kind A · utility
29Cited by
0References
12Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Sep 3, 1997 |
| Grant date | Sep 7, 1999 |
| Priority date | — |
| Expiry date | Sep 3, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is a method for enhancing the analgesic efficacy of a locally applied opioid analgesic or local anesthetic agent in a mammal having an impermeable perineurium barrier sheet about the peripheral sensory nerves at the site of action of the analgesic or anesthetic agent. The method involves applying to that site an effective amount of the analgesic or anesthetic agent dissolved in a hyperosmolar solution having an osmolality of above 300 mOsm/l.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.