Immediate early protein from Kaposi's sarcoma-associated herpesvirus, DNA encoding same and uses thereof

US5948676A · kind A · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Yuan Chang · New York, US
• Roy A. Bohenzky · Mountain View, US
• James J. Russo · New York, US
• Isidore S. Edelman · New York, US
• Patrick S. Moore · New York, US

Key dates

• Filing date: Oct 10, 1996
• Grant date: Sep 7, 1999
• Expiry date: Oct 10, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/16422
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides an isolated nucleic acid molecule which encodes Kaposi's Sarcoma-Associated Herpesvirus (KSHV) immediate early protein (IEP). This invention provides an isolated polypeptide molecule which encodes KSHV immediate early protein. This invention provides an antibody specific to the polypeptide. Antisense and triplex oligonucleotide molecules are also provided. This invention provides a vaccine for Kaposi's Sarcoma (KS). This invention provides methods of vaccination, prophylaxis, diagnosis and treatment of a subject with KS and of detecting expression of a DNA virus associated with Kaposi's sarcoma in a cell.