Methods for treatment of multiple sclerosis utilizing peptide analogues of human myelin basic protein
US5948764A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 9, 1997 |
| Grant date | Sep 7, 1999 |
| Priority date | — |
| Expiry date | Jan 9, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed toward peptide analogues of human myelin basic protein for use in the treatment of multiple sclerosis. Within one aspect, peptide analogues suitable for treating multiple sclerosis are provided which are at least seven amino acids long and derived from residues 86 to 99 of human myelin basic protein. In addition, such analogues may be altered from the native sequence at positions 87, 88, 97, 98 or 99 to a D-amino acid. Additional alterations may be made at other positions. Pharmaceutical compositions containing these peptide analogues are also provided, as well as methods for treating multiple sclerosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.