Benzothiopene compounds, and uses and formulations thereof

US5948795A · kind A · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• David Thompson Berg · Beech Grove, US
• George J. Cullinan · Trafalgar, US
• Brian W. Grinnell · Indianapolis, US
• Mark A. Richardson · Indianapolis, US

Key dates

• Filing date: Jun 25, 1997
• Grant date: Sep 7, 1999
• Expiry date: Jun 25, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D333/56
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel benzothiophenes, ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 are independently --OH, --OCO(C.sub.1 -C.sub.6 alkyl), --O(CO)O(C.sub.1 -C.sub.6 alkyl), --OCO--Ar, where Ar is phenyl or substituted phenyl, or --O(CO)O--phenyl; and R.sub.4 is N-pyrrolidinyl, N-piperidinyl, or N-hexamethyleneimino, and intermediates thereof, and the uses and formulations thereof, are provided by the present invention.