Methods for inhibiting bacterial cytotoxicity

US5948815A · kind A · utility

Assignee

• The Regents of the University of California · US

Inventors

• Suzanne M. J. Fleiszig · Berkeley, US
• David Evans · Arlington, US

Key dates

• Filing date: Mar 13, 1998
• Grant date: Sep 7, 1999
• Expiry date: Mar 13, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides methods and compositions for reducing microbial cytotoxicity to a cell, by contacting a cell subject to extracellular microbial cytotoxicity with an effective amount of at least one of genistein or a genistein derivative. In preferred embodiments, the microbe is a gram-negative bacterium, a non-Enterobacteriaceae or a Pseudomonas aeruginosa or cepacia and the host cell is a mammalian epithelial cell, especially a lung epithelial cell or a corneal epithelial cell. The genistein or genistein derivative may be administered prophylactically prior to infection, subsequent thereto and/or in conjunction with conventional antibiotic therapies.