Stabilization of somatotropins and other proteins by modification of cysteine residues
US5951972A · kind A · utility
14Cited by
13References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 6, 1995 |
| Grant date | Sep 14, 1999 |
| Priority date | — |
| Expiry date | Feb 6, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/50
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to physiologically-active derivatized natural and recombinant mammalian and human proteins and polypeptides. The invention provides chemical methods for derivatizing natural and recombinantly-derived proteins or polypeptides containing cysteine residues, either naturally or through site specific mutageneses. The pharmaceutical compositions containing the derivatized proteins and/or polypeptides are formulated to provide stable, long-acting compositions of such proteins and/or polypeptides, previously difficult to achieve.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.