Assay for inhibitors of a 24 kD cytoplasmic protease which activates DNA fragmentation in apoptosis
US5952189A · kind A · utility
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Key dates
| Filing date | Mar 26, 1997 |
| Grant date | Sep 14, 1999 |
| Priority date | — |
| Expiry date | Mar 26, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method is disclosed for assaying for inhibitors of a 24 kDa cytoplasmic protease associated with apoptosis. The protease has a defined amino acid composition, activity against the elastase-like substrate MAAVP, and induces DNA fragmentation associated with apoptosis in isolated U937 cell target nuclei.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.