Method for separating unmodified hemoglobin from cross-linked hemoglobin
US5952470A · kind A · utility
2Cited by
17References
20Claims
0Family size
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Key dates
| Filing date | Jun 7, 1995 |
| Grant date | Sep 14, 1999 |
| Priority date | — |
| Expiry date | Jun 7, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/805
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method for separating unmodified hemoglobin from cross-linked hemoglobin in a hemoglobin solution. The method involves contacting the hemoglobin solution with a least one dissociating agent to form a dissociation solution wherein unmodified tetrameric hemoglobin is dissociated to form hemoglobin dimers. The hemoglobin dimers are then separated from the dissociation solution, while retaining the cross-linked hemoglobin in the dissociation solution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.