2R,4S,R, S- and 2S,4R,R,S-hydroxyitraconazole
US5952502A · kind A · utility
18Cited by
16References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 12, 1997 |
| Grant date | Sep 14, 1999 |
| Priority date | — |
| Expiry date | Nov 12, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D249/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method of preparation of optically pure isomers of hydroxyitraconazole, in particular the two cis dioxolane diastereomers of the sec-butyl (R,S)-isomer, and to phosphate and sulfate derivatives thereof is disclosed. Pharmaceutical compositions containing these compounds and to their use for the treatment of fungal infection are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.