Patent · US Expired

Immunogenic hybrid protein OprF-OprI derived from Pseudomonas aeruginosa membrane proteins

US5955090A · kind A · utility

5Cited by

0References

6Claims

0Family size

Assignee

CHIRON BEHRING GMBH & CO. · DE

Inventors

Bernhard Knapp · Marburg, DE
Klaus-Dieter Hungerer · Marburg, DE
Michael Broker · Marburg, DE
Bernd-Ulrich von Specht · Endingen am Kaiserstuhl, DE
Horst Domdey · Schwanau, DE

Key dates

Filing date	Dec 14, 1995
Grant date	Sep 21, 1999
Priority date	—
Expiry date	Dec 14, 2015

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S424/829
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to a hybrid protein comprising the Pseudomonas aeruginosa outer membrane protein I (OprI) which is fused with its amino terminal end to the carboxy-terminal end of a carboxy-terminal portion of the Pseudomonas aeruginosa outer membrane protein F (OprF), as well as to monoclonal or polyclonal antibodies against this hybrid protein. Both, the hybrid protein and the antibodies directed to the hybrid protein confer protection against an infection by Pseudomonas aeruginosa to laboratory animals or man.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.