Biosensor device and method
US5955379A · kind A · utility
21Cited by
17References
10Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Apr 24, 1997 |
| Grant date | Sep 21, 1999 |
| Priority date | — |
| Expiry date | Apr 24, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/904
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A biosensor apparatus for detecting a binding event between a ligand and receptor. The apparatus includes an electrode substrate coated with a high-dielectric hydrocarbon-chain monolayer, and having ligands attached to the exposed monolayer surface. Binding of a receptor to the monolayer-bound ligand, and the resultant perturbation of the monolayer structure, causes ion-mediated electron flow across the monolayer. In one embodiment, the monolayers have a coil--coil heterodimer embedded therein, one subunit of which is attached to the substrate, and the second of which carries the ligand at the monolayer surface.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.