Cryptophycins

US5955423A · kind A · utility

Assignees

• UNIVERSITY OF HAWAII · US
• Wayne State University · US

Inventors

• Richard E. Moore · Honolulu, US
• Charles D. Smith · Charleston, US
• Gregory M. L. Patterson · Honolulu, US
• Susan L. Mooberry · Honolulu, US
• Thomas H. Corbett · Grosse Pointe Park, US
• Frederick A. Valeriote · Shelby Charter Township, US
• Trimurtulu Golakoti · Honolulu, US

Key dates

• Filing date: Jun 7, 1995
• Grant date: Sep 21, 1999
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/27
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods for producing novel cryptophycins from the Nostoc sp. of blue-green algae (cyanobacteria). Pharmaceutical compositions comprising novel cryptophycins are also provided, as are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells. Further provided are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells with drug resistant phenotypes, and to treat pathological conditions, such as neoplasia.