Thiamorphinans with neuroprotective activity
US5955493A · kind A · utility
0Cited by
3References
21Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Apr 30, 1998 |
| Grant date | Sep 21, 1999 |
| Priority date | — |
| Expiry date | Apr 30, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to morphinan derivatives that are neuroprotective against excitatory amino acid (EAA) cytotoxicity. In particular, morphinan derivatives of the invention act as antagonists at the ionotropic NMDA (N-methyl-(D)-aspartic acid) receptor and are useful as protective agents against peripheral and central nervous system NMDA-receptor mediated toxicity and convulsions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.